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Mandel Grace  
#1 Posted : Sunday, March 22, 2020 10:40:48 AM(UTC)
Mandel Grace

Rank: Newbie

Groups: Registered
Joined: 3/22/2020(UTC)
Posts: 3

ÿþWe recently reported a new UV-curable polyurethane-methacrylate (PUMA) resin puma creepers that has excellent qualities as a disposable microfluidic substrate for clinical diagnostic applications. This article discusses strategies to improve the production yield of PUMA chips that contain dense and high-aspect-ratio features, which presents unique challenges in demolding and bonding steps. These fabrication improvements were deployed to produce a microfiltration device that contained closely spaced and high-aspect-ratio columns.

We recently reported a new UV-curable polyurethane-meth-acrylate (PUMA) resin that is non-elastomeric and has excellent qualities as a disposable microfluidic substrate, especially for clinical diagnostic applications. 18 This PUMA substrate is transparent optically, resistant to biofouling, compatible with many chemicals encountered in microfluidic applications, curable to puma fenty a typical thickness (about the thickness of glass slides), bondable to form enclosed devices easily.

They are prone to compression-related damage. Losses during these two steps must not be convoluted with the yield of UV-casting, which is highly puma slides consistent once the UV dosage and the thickness of the resin is properly optimized. We have devoted a great deal of effort to troubleshoot the demolding and bonding steps, and developed techniques to eliminate inconsistencies and inadvertent damages to the replicated microstructures. The result is an increased quality control and improvement in yield.

Polydimethylsiloxane (PDMS) molds were prepared according to procedures described previously 18 from a molding master that was prepared by deep-reactive ion puma rihanna etching of silicon wafer and subsequently silanized with PUMA resin , CT) was dispensed to 3-mm thickness onto the PDMS mold, then covered with a sheet of cellophane tacked to a clear polypropylene backing (8-mil thick) to prevent oxygen inhibition of the cross-linking reaction ( Fig. 1A ).

Causing delamination from the adhesive. The best tubing among those evaluated was the 1/16-in OD PTFE tubing. Although it is nearly impossible to chemically bond to PTFE tubings, that can be circumvented by covering the external surface with a polyolefin heat-shrink. Then the PTFE tubing may be inserted either directly into a 1/16-in diameter hole and secured with additional resin, or into a 1/8-in hole with a supplemental PU tubing (1/8-in OD) puma suede classic as a shear anchor, and lastly secured with additional resin.

A 180° bend was incorporated in the design to help troubleshooting if there were directional issues in either the replication or demolding process. As evident in Fig. 2A , the columns produced in PUMA had a sharp vertical profile with no evidence of leaning.We found that for low-aspect-ratio (H/W<�1) features the cured PUMA resin could be released from the PDMS mold either by (1) peeling the mold slightly away from the cured resin or (2) wedging a scalpel between the resin UserPostedImage and the mold to gently lift up the resin.
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