However, the interactions between Sildenafil (the active ingredient in Fildena) and antibiotics or antifungal medications can be relevant to any formulation of Fildena Double 200 Mg, including higher dosages. Specifically, certain antibiotics and antifungal medications can interact with Sildenafil and may increase the risk of side effects or alter the metabolism of the medications in the body. In general, antibiotics or antifungal medications that are known as CYP3A4 inhibitors can potentially interact with Sildenafil. CYP3A4 is an enzyme in the liver that plays a crucial role in breaking down medications, including Sildenafil. When CYP3A4 inhibitors are used with Fildena Double 200 Mg, they can slow down the metabolism of Sildenafil, leading to higher levels of the medication in the body, which may increase the risk of side effects. If you are taking Fildena or any other medication containing Sildenafil and need to use antibiotics or antifungal medications, it's crucial to inform your healthcare provider about all the medications you are taking. They can check for potential interactions and make necessary adjustments to your treatment plan to ensure safe and effective use of the medications. Never combine medications without proper medical guidance, as drug interactions can be complex and potentially harmful. Always consult your doctor before starting or stopping any medications, and follow their advice to avoid adverse effects and ensure your safety.