97% of the bit is handled generally by methods for conjugation with glucuronic destructive to convey glucuronides. Tapentadol is furthermore utilized into N-desmethyl tapentadol (13%) by CYP2C9 and CYP 2C19. CYP2D6 is related with the game plan of the metabolite, hydroxy tapentadol (2%). All metabolites are torpid.