Raw Antiinflammatory Antioxidize effect powder Phenethyl caffeate



English name: Phenethyl caffeate
Alias: Caffeic acid phenethyl ester (CAPE)
English alias Phenethyl caffeiate; 3,4-Dihydroxy-trans-cinnamic acid phenethyl ester
Product Name: Caffeic acid phenylethyl
CAS No.: 115610-29-2
Molecular Formula: C17H16O4
Molecular Weight: 284.30700

Propolis has a wide range of plant sources, and its chemical composition is extremely complex. So far, more than 20 chemical components have been identified from propolis and more than 300 types, including flavonoids, phenolic acids, decanoic acids, steroids, and amino acids. Classes and other substances. Caffeic acid phenethylester (CAPE) has been identified as one of the main active components in propolis, and many biological activities of propolis are related to CAPE. Therefore, CAPE is a hot topic in the study of active ingredients of foreign propolis in recent years.Phenethyl caffeate
The CAPE structure contains a strong antioxidant catechol structure. Sudina's experiments showed that CAPE can completely block the production of active oxidants in neutrophils at 10 μM, blocking the xanthine oxidase system. Moreover, it was found that propolis containing CAPE has stronger antioxidant activity than CAPE, and CAPE activity is stronger than that of another important component of propolis, galangal, indicating that CAPE is an important component of antioxidant activity. . Ozytlrt et al. studied the antioxidant activity of propolis extracts against acute kidney injury in rats, indicating that the antioxidant effect of propolis extracts is better than VE, and CAPE is one of the main components. The effect of CAPE on lipid peroxides in burned rat serum was found to be that CAPE can reduce SOD consumption by eliminating active oxidizing substances and inhibiting the activity of xanthine oxidase (X0) and NOS, thus playing an antioxidant role. .
Anti-inflammatory effect
Studies have shown that propolis ethanol extract containing CAPE can inhibit carrageenan-induced adjuvant arthritis, pleurisy, and rat paw edema. Extracts that do not contain CAPE have no such activity, suggesting that CAPE is anti-inflammatory. The main component of the effect. In addition, CAPE can inhibit the production of NO. N0 is a free radical produced by iNOS to catalyze the production of L-arginine. Excessive NO can cause damage to the body, and in autoimmune diseases such as rheumatoid arthritis and ulcerative colon. Inflammation and NO synthesis in systemic lupus erythematosus increase. Yun et al. reported that CAPE can inhibit the increase of N0 induced by LPS + IFN-γ, mainly due to the inhibition of iNOS gene by CAPE acting on the NF-kB locus of the iNOS promoter and directly inhibiting the catalytic activity of iNOS activity. Transcription, so CAPE can inhibit the expression of NOS gene and play an anti-inflammatory role. In addition, Michaluart et al. and Mirzoeva et al. reported that CAPE can also inhibit the synthesis of prostaglandin (PG) and leukotrienes. PG is produced by catalysis of arachidonic acid (AA) under COX. There are two isoforms of C0X. It is COX-1 and OX-2, and PG plays an important role in the formation of inflammation. CAPE acts by inhibiting the release of arachidonic acid from the cell membrane and inhibiting the activity of COX-1 and COX-2. Antioxidant effect.
Anti-tumor effect
Propolis contains CAPE, quercetin, isoprenyl esters, rosarylin, ganoderma, and terpenes, polysaccharides and other substances that have anticancer activity, can inhibit tumor cell proliferation, and have a certain toxic effect on cancer cells. , And CAPE has a specific lethal effect on tumor cells. Jeng et al. believe that CAPE is involved in the induction of natural cell death and cytotoxicity to malignant lesions. CAPE can be improved at a very small concentration by the tumor factor (12-O-tetradecanoyl-pyritol-13- Acid ester) induced inflammatory reaction. Frenkel et al. demonstrated the probability of occurrence through animal testing and confirmed that it can effectively suppress foreign carcinogens. Li et al. showed that CAPE had better inhibitory activity on HL 60, Bel 7402 and He1a tumor cells, and the inhibition rate reached 56. 05 %, 48 . 78% and 56. 05 %. Chen et al. showed that the IC50 concentration of CPAE on HL-60 cells was 1. 0 μ M , 5 . 0 μ M and 1 . 5 μM inhibits the synthesis of DNA, RNA, and protein, respectively. Studies at home and abroad have shown that CAPE in propolis has a very strong effect on melanoma, colon cancer, and gastric cancer cell lines, and exhibits the characteristics of inhibiting cancer cells.