Yes, Can Priapism Damage be Reversed potentially cause nerve damage. Priapism is a condition characterized by prolonged and often painful erections that last for hours and occur without sexual stimulation. If left untreated, the prolonged lack of blood flow can lead to tissue damage in the penis, including nerve damage. The sustained pressure and lack of oxygen can harm the erectile tissue, leading to fibrosis and potential loss of erectile function. If the condition persists, it can affect the nerves in the area, potentially leading to complications such as permanent erectile dysfunction.